Plenary Session
Sunday, June 4 • 5:30 - 6:30 PM
Bioorthogonal chemistry, the journey from basic science to clinical translation
Carolyn Bertozzi
Stanford University
The Nobel Prize in Chemistry 2022
Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford University, and an Investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree in Chemistry from Harvard University in 1988 and her Ph.D. in Chemistry from UC Berkeley in 1993. After completing postdoctoral work at UCSF in the field of cellular immunology, she joined the UC Berkeley faculty in 1996. In June 2015, she joined the faculty at Stanford University coincident with the launch of Stanford’s ChEM-H Institute.
Prof. Bertozzi’s research interests span the disciplines of chemistry and biology with an emphasis on studies of cell surface glycosylation pertinent to disease states. Her lab focuses on profiling changes in cell surface glycosylation associated with cancer, inflammation and bacterial infection, and exploiting this information for development of diagnostic and therapeutic approaches, most recently in the area of immuno-oncology. She has been recognized with many honors and awards for her research accomplishments. She is an elected member of the Institute of Medicine, National Academy of Sciences, and American Academy of Arts and Sciences. She has been awarded the Lemelson-MIT Prize, the Heinrich Wieland Prize, and a MacArthur Foundation Fellowship, among many others.
Major Awards:
Welch Award in Chemistry (2022); The Dickson Prize in Medicine, University of Pittsburgh (2022); Dr H.P. Heineken Prize for Biochemistry and Biophysics (2022); Wolf Prize in Chemistry (2022); AAAS Lifetime Mentor Award (2022); Helen Dean King Award, The Wistar Institute (2022); STATUS List 2022 (Stat News); President’s Innovator Award, Society for Glycobiology (2020); Nagoya Medal (2020); Chemistry for the Future Solvay Prize (2020); National Academy of Sciences John J. Carty Award for the Advancement of Science (2020); The Gustavus John Esselen Award for Chemistry in the Public Interest (2019), Fellow of the Royal Society (2018); National Inventor’s Hall of Fame Inductee (2017); American Chemical Society Arthur C. Cope Award (2017); National Academy of Sciences Award in the Chemical Sciences (2016); Ernest Orlando Lawrence Award of the U.S. Department of Energy (2015); UCSF 150th Anniversary Alumni Excellence Award (2015); Hans Bloemendal Award (Radboud Univ. Nijmegen) (2013); Heinrich Wieland Prize (2012); Tetrahedron Young Investigator Award (2011); Lemelson-MIT Prize (2010); Albert Hofmann Medal (Univ. Zurich) (2009); Harrison Howe Award (2009); W. H. Nichols Award (2009); Willard Gibbs Medal (2008); Roy L. Whistler International Award in Carbohydrate Chemistry (2008); Li Ka Shing Women in Science Award (2008); Ernst Schering Prize (2007); T.Z. and Irmgard Chu Distinguished Professorship in Chemistry (2005); Havinga Medal, Univ. Leiden (2005); Iota Sigma Pi Agnes Fay Morgan Research Award (2004); Irving Sigal Young Investigator Award of the Protein Society (2002); Fellow of the American Association for the Advancement of Science (2002); Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching (2001); UC Berkeley Distinguished Teaching Award (2001); ACS Award in Pure Chemistry (2001); Merck Academic Development Program Award (2000); UC Berkeley Department of Chemistry Teaching Award (2000); Presidential Early Career Award in Science and Engineering (PECASE) (2000); MacArthur Foundation “Genius” Award (1999); Camille Dreyfus Teacher-Scholar Award (1999); Arthur C. Cope Scholar Award (ACS) (1999); Beckman Young Investigator Award (1998); Prytanean Faculty Award (1998); Glaxo Wellcome Scholar (1998); Research Corporation Research Innovation Award (1998); Office of Naval Research Young Investigator Award (1998); Horace S. Isbell Award in Carbohydrate Chemistry (ACS) (1997); Alfred P. Sloan Research Fellow (1997); Burroughs Wellcome New Investigator Award in Pharmacology (1997); Pew Scholars Award in the Biomedical Sciences (1996); Exxon Education Fund Young Investigator Award (1996); Camille and Henry Dreyfus New Faculty Award (1995)
Bioorthogonal chemistry, the journey from basic science to clinical translation
Here I present an overview of the origins of bioorthogonal chemistry as an enabling tool for biological research, particularly in glycoscience, and modern applications in the development of new therapeutic modalities.
Plenary Session
Monday, June 5 • 8:00 - 9:00 AM
Nanoparticle Shape Effects on Nano-Bio Interactions
Teri W. Odom
Northwestern University
Teri W. Odom is the Joan Husting Madden and William H. Madden, Jr. Professor of Chemistry and Chair of the Chemistry Department at Northwestern University. She received her B.S. in Chemistry from Stanford University and Ph.D. in Chemical Physics from Harvard University. Odom carried out postdoctoral work at Harvard University before starting her career at Northwestern University in 2002. She is an expert in designing structured nanoscale materials that exhibit extraordinary size and shape-dependent optical and physical properties.
Odom is a Member of the American Academy of Arts and Sciences and a Fellow the American Chemical Society (ACS), the Royal Society of Chemistry (RSC), Optica, the American Physical Society (APS), the Materials Research Society (MRS), and the American Institute of Medical and Biological Engineering (AIMBE). Select honors and awards include: the RSC Centenary Prize; the ACS National Award in Surface Science; a Research Corporation TREE Award; a U.S. Department of Defense Vannevar Bush Faculty Fellowship; a Radcliffe Institute for Advanced Study Fellowship at Harvard University; an NIH Director’s Pioneer Award; the MRS Outstanding Young Investigator Award; the National Fresenius Award from Phi Lambda Upsilon and the ACS; an Alfred P. Sloan Research Fellowship; and a David and Lucile Packard Fellowship in Science and Engineering.
Odom was founding Chair of the Noble Metal Nanoparticles Gordon Research Conference (GRC) and founding Vice-Chair of the GRC on Lasers in Micro, Nano, Bio Systems. She was an inaugural Associate Editor for Chemical Science and founding Executive Editor of ACS Photonics. She is Editor-in-Chief of Nano Letters.
Nanoparticle Shape Effects on Nano-Bio Interactions
Anisotropic gold nanoparticles exhibit shape-dependent properties beneficial for drug delivery vehicles, imaging probes, and therapeutic agents. Although increased therapeutic efficacy has been realized, direct visualization of how engineered nanoparticles interact with specific organelles or cellular components has been limited. Such interactions will have implications for fundamentals in cancer biology as well as in the design of translational nanoconstructs. This talk will describe how drug-loaded gold nanostars can behave as optical probes to interrogate how targeting nanoconstructs interact with cells at the nanoscale. We will focus on model cancer cell systems that can be used to visualize how gold nanoconstructs target cells, rotate, and translate on the plasma membrane and are endocytosed and trafficked intracellularly. Differences in single-particle dynamics reveals how nanoparticle geometry affects binding to cell-membrane receptors and internalization. That nanoparticle shape can preserve ligand activity of nanoconstructs extracellularly as well as dictate spatial organization intracellularly will have important implications for engineering designer nanoconstructs for nanomedicine.
Plenary Session
Tuesday, June 6 • 8:00 - 9:00 AM
Small Science and Big Science Entanglement: The Advent of a New Era of Synchrotron Light Sources for Chemical Research
Tsun-Kong Sham, MCIC
University of Western Ontario
Dr. Tsun-Kong Sham received his BSc from the Chinese University of Hong Kong and PhD from the University of Western Ontario (1975). He then joined Brookhaven National Laboratory and returned to Western in 1988. Since 2002, he has been a Tier I Canada Research Chair in Materials and Synchrotron Radiation. He served as the Director of the Canadian Synchrotron Radiation Facility at the Synchrotron Radiation Center, University of Wisconsin-Madison (1999-2008), leading innovation, training scientists and transferring technology to the Canadian Light Source (CLS). He was appointed Officer of Order of Canada in 2016 for his seminal science and service to the community.
Dr. Sham is at the forefront of the interplay of materials functionality and synchrotron spectroscopy. He has provided leadership at the R&D of beamlines at CLS.
Dr. Sham served as a member of the Board of CLS (2000-2006). He is a long-standing member of the International X-ray Absorption Society and served as its Chair (2003-2006). In 2012, he helped found the Soochow-Western Centre for Synchrotron Radiation Research and served as the Chair. He is the Chair of the Ontario Synchrotron Consortium, currently working with CISR (Canadian Institute for Synchrotron Radiation) toward a next generation synchrotron for Canada.
Small Science and Big Science Entanglement: The Advent of a New Era of Synchrotron Light Sources for Chemical Research
The matured third generation synchrotron light sources have provided an exciting playground and unprecedented opportunities for chemical research. The very bright, energy-tunable, highly collimated, and pulsed light sources are making tunable X-rays readily available for all branches of science and technology: from proteins to drug delivery, from CO2 capture to environmental protection, from energy materials to energy storage and conversion, from cultural heritage materials to preservation and conservation, and from soil science to agricultural advancement, just to name a few.
In this talk, I will describe the powerful synchrotron technology and its applications. More importantly, I will present how synchrotron technology came about, especially in the Canadian context and how the science community can benefit from this powerful tool for research. The impact of synchrotron on the sociology of science will also be noted. The world is now marching toward the fourth-generation synchrotron technology which includes diffraction limited-electron storage ring and free-electron laser. The Canadian synchrotron community is in pursue of the next generation synchrotron and will engage the scientific community and industry moving forward.
Plenary Session
Wednesday, June 7 • 8:00 - 9:00 AM
Towards a Panacea in Chemical Sensing
Janusz Pawliszyn, FCIC
University of Waterloo
The primary focus of Professor Pawliszyn’s research program is the design of highly automated and integrated instrumentation for isolating analytes from complex matrices and the subsequent separation, identification, and determination of these species. The primary separation tools used by his group are Gas Chromatography, Liquid Chromatography, and Capillary Electrophoresis coupled to a variety of detection systems, including a range of mass spectrometry techniques as well as ambient ionization techniques. Currently, his research is focusing on the elimination of organic solvents from the sample preparation step and miniaturization of the sampling devices to facilitate on-site monitoring and in-vivo analysis. Several alternative techniques to solvent extraction are investigated including the use of coated fibers, packed needles, membranes, and supercritical fluids. Dr. Pawliszyn is exploring the application of computational and modeling techniques to enhance sample preparation, chromatographic separations, and detection performance. The major area of his interest involves the development and application of imaging detection techniques for microcolumn chromatography, capillary electrophoresis, and microchip separation devices.
Professor Pawliszyn has supervised 60 PhD and 70 MS students, and he is an author of over 700 scientific publications and a book on Solid Phase Microextraction. His Hirsch Index (H-index) is 103. He is a Fellow of the Royal Society of Canada, Editor-in-Chief of Trends in Analytical Chemistry and Green Analytical Chemistry. He initiated a conference, “ExTech”, focusing on new advances in sample preparation and disseminating new scientific developments in the area, which meets every year in a different part of the world. He received the 1995 McBryde Medal, the 1996 Tswett Medal, the 1996 Hyphenated Techniques in Chromatography Award, the 1996 Caledon Award, the Jubilee Medal 1998 from the Chromatographic Society, U.K., the 2000 Maxxam Award from Canadian Society for Chemistry, the 2000 Varian Lecture Award from Carleton University, the Alumni Achievement Award for 2000 from Southern Illinois University, the Humboldt Research Award for 2001, 2002 COLACRO Medal, 2003 Canada Research Chair, in 2006 he has been elected to the most cited chemists by ISI, in 2008 he received A.A. Benedetti-Pichler Award from Eastern Analytical Symposium, 2008 Andrzej Waksmundzki Medal from Polish Academy of Sciences, 2008 Manning Principal Award, 2010 Torbern Bergman Medal from the Swedish Chemical Society, 2010 Ontario Premier’s Innovation Award, 2010 Marcel Golay Award, 2010 ACS Award in Separation Science and Technology, 2011 PittCon Dal Nogare Award, 2012 E.W.R. Steacie Award, 2013 CIC Environmental Research and Development Award, 2013 CIC LeSueur Memorial Award, 2015 Maria Skłodowska-Curie Medal from Polish Chemical Society, 2015 Halász Medal Award from the Hungarian Society for Separation Sciences, 2017 Pittsburgh Conference Analytical Chemistry Award, the 2017 Eastern Analytical Symposium Award for Outstanding Achievements in the Fields of Analytical Chemistry, 2018 ACS Award in Chromatography, 2018 North American Chemical Residue Workshop Excellence Award, 2019 Talanta Medal and 2022 Tswett-Nernst Award. He presently holds the title of University Professor and Canada Research Chair.
Towards a Panacea in Chemical Sensing
The development of devices to facilitate the chemical determination of organic compounds in complex matrices has largely consisted of two main directions. One is the design of sensors, which are simple, portable devices that enable good performance for the on-site analysis of real samples, even in-vivo. However, sensors are typically limited to single-component determination, with selectivity determined by membrane and/or readout characteristics. The second direction entails the use of hyphenated separation using mass spectrometry technologies, such as GC/MS and LC/MS. Indeed, the rapid development of mass spectrometry and multidimensional approaches in recent years has enabled multicomponent determination and the comprehensive characterization of the composition of complex samples. The main limitation of this direction is the demands required to prepare complex samples in a manner that enables good analytical performance. Miniaturized, on-site versions of the instruments used in this stream are already available or being constructed, so issues related to size and portability are currently being addressed; however, what are missing are effective sampling/sample-preparation tools.
To address the above challenges, we propose combining sensor a design strategy, thus providing good isolation selectivity, and chromatography/spectrometry technologies, which facilitate multicomponent characterization with high accuracy, reproducibility, and precision. For this approach to be effective, the “sensor” must be able to accumulate enough analyte during sampling to facilitate sensitive determinations. To accomplish this task, we have been designing matrix-compatible high-analyte-capacity probes with flexible shapes and morphologies that facilitate GC/MS, LC/MS, or direct mass spectrometry readout. These probes consist of thin, matrix-compatible coatings consisting of extraction phases made up of sorbent particles and a binder, which forms a protective layer that prevents direct contact with the matrix particles while also facilitating the analytes’ adhesion to the support. The designed probes enable non-exhaustive sampling in manner similar to sensors, but much longer extraction times are used to allow the accumulation of sufficient quantities of analytes to allow sensitive detection. Such chemical biopsy probes selectively enrich smaller molecules, which can diffuse though the protective layer formed by the binder while leaving the investigated system intact, thus preventing macromolecules in the sample from influencing the measurement quality. After completing the sampling/sample-preparation step, the probes are introduced to the analytical instrument where the analytes are isolated via thermal or solvent desorption.
This flexible solid-phase microextraction (SPME) approach has deployed for a wide range of the applications, with results demonstrating its superior performance compared to traditional approaches to the determination of complex samples [1]. In addition to better analytical performance, SPME possesses much better sustainability characteristics, as it eliminates or minimizes the use of organic solvents, making it an ideal tool for future generations of chemists. The main challenge in adopting the SPME approach is that, as with sensors, it is based on non-exhaustive sampling, whereas standard technologies utilize exhaustive approaches, with performance being evaluated based on the recovery of spiked analytes. This feature has led to some resistance to the adoption of SPME technologies by many regulatory agencies. However, despite this challenge, SPME technology remains commonly used in many areas where no good solutions exist. Furthermore, the application of SPME in various scientific disciplines is also fueled by its “green” features. During the talk, examples of different SPME designs that address important world challenges will be presented to help the audience gain a deeper appreciation of the impact of this chemical sensing approach.
- Chem. 2018, 90, 302−360
