John Paul Pezacki obtained his PhD in organic chemistry from McMaster University with the late John Warkentin, conducted postdoctoral studies at the University of Toronto on protein bioconjugation and cross-linking as well as nitric oxide signaling with Ronald Kluger, and then at the Scripps Research Institute with Peter G. Schultz working on a genomic approaches to the study of viral infections. He is a full professor at the University of Ottawa where the overarching theme of his research program is the development and application of chemical tools for the study of host-pathogen interactions. Recent advances include the development of bioorthogonal and activity-based probes with unique chemical reactivity, the identification of cellular factors influencing the virulence of RNA viruses, such as hepatitis C virus, as well as the development of tools to investigate the mechanisms of action of non-coding RNAs during infection and the host response. The discoveries that stem from the development and application of these new chemical/biochemical methodologies are the result of his continuing efforts to elucidate biological mechanisms of infection and identify targets for therapeutic intervention.
John Paul Pezacki
University of Ottawa